Virulence of metallo-beta-lactamase-producing Pseudomonas aeruginosa in vitro and in vivo.

نویسندگان

  • S Aoki
  • Y Hirakata
  • A Kondoh
  • N Gotoh
  • K Yanagihara
  • Y Miyazaki
  • K Tomono
  • Y Yamada
  • S Kohno
  • S Kamihira
چکیده

We evaluated the virulence of Pseudomonas aeruginosa carrying bla(IMP), a metallo-beta-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia model. The presence of bla(IMP) did not practically change the virulence of the parent strain, and ciprofloxacin was effective against infection with P. aeruginosa carrying bla(IMP).

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 48 5  شماره 

صفحات  -

تاریخ انتشار 2004